Article Published By: http://www.vrp.com/minerals/the-hidden-effects-of-fluoride-and-how-you-can-mitigate-them?
Fluoride may have been added to the public water supply to protect your teeth–but believe it or not, research shows that increased intake of this compound could be having quite the opposite effect on your overall health. In fact, a quick review of the research might leave you wondering if there’s any system in your body that isn’t susceptible to fluoride’s negative influence.
Take its effect on thyroid function, for starters. Both animal and human studies have shown that fluoride can affect levels of thyroid hormones–including trioodothyronine (T3), free T3, thyroxine (T4) and free T4. Further research has linked long-term fluoride exposure to immune imbalances, including reduced immune cell cooperation–especially among individuals who also have suboptimal thyroid function.
Bones are equally affected by fluoride’s effects, with studies showing that it can affect mineral metabolism and bone density, while contributing to poor cellular health and oxidative stress in osteoblasts (bone-building cells). Fluoride exposure also may result in suboptimal heart health as research has linked increased fluoride intake to decreased arterial compliance and flexibility affecting cardiovascular health. Finally, your pancreas, liver and kidneys can also be affected: Animal and human studies indicate that fluoride may affect glucose tolerance and insulin secretion from beta cells, promote free radical generation, and impact liver and kidney structure and functioning.
Animal research suggests that even fertility could be impacted thanks to fluoride, with exposure resulting in imbalances in sperm count, motility and density– and recent U.S. population studies have noted a similar association between fertility and fluoride levels in humans, as well.
Because fluoride is a member of the halogen family–which includes iodine, chlorine and bromine–it competes with these elements in the physiological function of certain organs, such as iodine-dependent breast and thyroid tissue. The good news, however, is that taking simple steps to replenish your iodine stores with a high-quality daily supplements–such as VRP’s Iodoral®–may be enough to keep fluoride uptake and its potential negative effects at bay.
Be sure to pair your daily iodine supplement with ample amounts of riboflavin and niacin–both found in VRP’s ATP Cofactors–since both B vitamins play a critical role in iodine’s absorption into your cells, while supporting cellular energy production and encouraging fluoride excretion.
In addition to boosting your iodine stores, you should also optimize your intake of a number of essential and trace minerals, including sodium, chloride, calcium, magnesium, potassium and zinc. Chloride in particular can be a vital ally in your body’s efforts to deal with excess fluoride–and luckily, getting enough of it could be as easy as eating more salt. But not just any salt. Instead, look to VRPs Celtic Sea Salt–an all-natural form of salt, which promotes healthy mineralization of your body and offers support for healthy cellular function.
1. Inkielewicz-Stepniak I, Czarnowski W. Oxidative stress parameters in rats exposed to fluoride and caffeine. Food Chem Toxicol. 2010 Jun;48(6):1607-11.
2. Morales-González JA, Gutiérrez-Salinas J, García-Ortiz L, et al. Effect of sodium fluoride ingestion on malondialdehyde concentration and the activity of antioxidant enzymes in rat erythrocytes. Int J Mol Sci. 2010 Jun 11;11(6):2443-52.
3. Shivarajashankara YM, Shivashankara AR, Bhat PG, et al. Lipid peroxidation and antioxidant systems in the blood of young rats subjected to chronic fluoride toxicity. Indian J Exp Biol. 2003 Aug;41(8):857-60.
4. Takahashi K, Akiniwa K, Narita K. Regression analysis of cancer incidence rates and water fluoride in the U.S.A. based on IACR/IARC (WHO) data (1978-1992). International Agency for Research on Cancer. J Epidemiol. 2001 Jul;11(4):170-9.
5. Wang H, Yang Z, Zhou B, et al. Fluoride-induced thyroid dysfunction in rats: roles of dietary protein and calcium level. Toxicol Ind Health. 2009 Feb;25(1):49-57.
6. Bachinskiĭ PP, Gutsalenko OA, Naryzhniuk ND, et al. Action of the body fluorine of healthy persons and thyroidopathy patients on the function of hypophyseal-thyroid the system. Probl Endokrinol (Mosk). 1985 Nov-Dec;31(6):25-9.
7. Balabolkin MI, Mikhaĭlets ND, Lobovskaia RN, et al. The interrelationship of the thyroid and immune statuses of workers with long-term fluorine exposure. Ter Arkh. 1995;67(1):41-2.
8. Krishnamachari KA. Skeletal fluorosis in humans: a review of recent progress in the understanding of the disease. Prog Food Nutr Sci. 1986;10(3-4):279-314.
9. Yan X, Yan X, Morrison A, et al. Fluoride induces apoptosis and alters collagen I expression in rat osteoblasts. Toxicol Lett. 2011 Feb 5;200(3):133-8.
10. Xu H, Wang CH, Zhao ZT, et al. Role of oxidative stress in osteoblasts exposed to sodium fluoride. Biol Trace Elem Res. 2008 Summer;123(1-3):109-15.
11. Varol E, Akcay S, Ersoy IH, et al. Impact of chronic fluorosis on left ventricular diastolic and global functions. Sci Total Environ. 2010 May 1;408(11):2295-8.
12. Varol E, Akcay S, Ersoy IH, et al. Aortic elasticity is impaired in patients with endemic fluorosis. Biol Trace Elem Res. 2010 Feb;133(2):121-7.
13. García-Montalvo EA, Reyes-Pérez H, Del Razo LM. Fluoride exposure impairs glucose tolerance via decreased insulin expression and oxidative stress. Toxicology. 2009 Sep 19;263(2-3):75-83.
14. Menoyo I, Rigalli A, Puche RC. Effect of fluoride on the secretion of insulin in the rat. Arzneimittelforschung. 2005;55(8):455-60.
15. Chattopadhyay A, Podder S, Agarwal S, et al. Fluoride-induced histopathology and synthesis of stress protein in liver and kidney of mice. Arch Toxicol. 2010 Sep 22. Published Online Ahead of Print.
16. Itai K, Onoda T, Nohara M, et al. Serum ionic fluoride concentrations are related to renal function and menopause status but not to age in a Japanese general population. Clin Chim Acta. 2010 Feb;411(3-4):263-6.
17. Liu JL, Xia T, Yu YY, et al. The dose-effect relationship of water fluoride levels and renal damage in children. Wei Sheng Yan Jiu. 2005 May;34(3):287-8.
18. Izquierdo-Vega JA, Sánchez-Gutiérrez M, Del Razo LM. Decreased in vitro fertility in male rats exposed to fluoride-induced oxidative stress damage and mitochondrial transmembrane potential loss. Toxicol Appl Pharmacol. 2008 Aug 1;230(3):352-7.
19. Gupta RS, Khan TI, Agrawal D, et al. The toxic effects of sodium fluoride on the reproductive system of male rats. Toxicol Ind Health. 2007 Oct;23(9):507-13.
20. Freni SC. Exposure to high fluoride concentrations in drinking water is associated with decreased birth rates. J Toxicol Environ Health. 1994 May;42(1):109-21.
21. Abraham GE. The safe and effective implementation of orthoiodosupplementation in medical practice. The Original Internist. 2004;11(1):17-36.